guanidine synthesis

Yield:-

Reaction Conditions:

with sulfuric acid at 0; for 48 h;Temperature;

Steps:

1-5; 1-6 Embodiment 1: guanidine sulfate is prepared by the following method:

S1. Mix guanidine hydrochloride with a molar ratio of 2:1 and sulfuric acid with a mass fraction of 80%, and place guanidine hydrochloride in the sulfuric acid at a constant speed within 60s, and continuously stir at a stirring speed of 300 r/min during the period.Then react at 0°C for 48h to generate the reaction product and hydrogen chloride gas;S2. Suction filtration of the reaction product obtained in S1 while it is still hot, take the filtrate and cool it down to 10°C at a cooling rate of 5°C/10min, then stand for 2h, and filter to obtain crude guanidine sulfate; pass hydrogen chloride gas into hydrogen chloride In sodium aqueous solution, sodium chloride solution and water are generated;S3, place the crude guanidine sulfate prepared by S2 in water and stir and dissolve for 15 min under the condition of 400 r/min to obtain a stirring liquid; then heat the stirring liquid to 70 ° C, suction filtration while hot, take the filtrate at 5 ° C/10min The cooling rate was cooled to 20 ° C, and then left for 3 hours to prepare the pre-finished product;S4, filter the prefabricated product obtained in S3, and dry it at room temperature to obtain a finished product of guanidine sulfate.

References:

CN114436898,2022,A Location in patent:Paragraph 0038-0048