H-NLE-OME HCL synthesis
- Product Name:H-NLE-OME HCL
- CAS Number:3844-54-0
- Molecular formula:C7H16ClNO2
- Molecular Weight:181.66
327-57-1
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3844-54-0
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Yield:-
Reaction Conditions:
with nitrogen in ethanol
Steps:
24.a (a)
(a) (S)-2-[[(4-Methylphenyl)sulfonyl]amino]-1-hexanol, 4-methylbenzenesulfonate ester A suspension of L-norleucine (6.5 g., 49.5 mmole) in absolute ethanol (70 ml.) is cooled to 0° (ice bath) and saturated with HCl gas. The mixture is allowed to warm to room temperature and stirred overnight. A stream of nitrogen is then passed through the solution to remove the bulk of the HCl and the mixture is evaporated to dryness. The solid residue is triturated with isopropyl ether, filtered, and dried to give 9.10 g. of L-norleucine, methyl ester, monohydrochloride as a fluffy white solid; m.p. 131°-132°; [α]D =+15.4° (c=1.10, methanol). TLC (silica gel; methylene chloride:acetic acid:methanol, 8:1:1) Rf =0.51.
References:
E. R. Squibb & Sons, Inc. US4849414, 1989, A
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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3844-54-0
90 suppliers
$11.00/1g
1000210-73-0
0 suppliers
inquiry
3844-54-0
90 suppliers
$11.00/1g
1000210-73-0
0 suppliers
inquiry
3844-54-0
90 suppliers
$11.00/1g