Hoveyda-Snapper Desymmetrization Catalyst synthesis

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
1.2: 1 h / 0 - 20 °C
2.1: magnesium sulfate monohydrate / dichloromethane / 20 °C
3.1: sodium tetrahydroborate; hydrogenchloride / methanol / 1.5 h / 0 - 20 °C

References:

Fingerhut, Anja;Vargas-Caporali, Jorge;Leyva-Ramírez, Marco Antonio;Juaristi, Eusebio;Tsogoeva, Svetlana B. [Molecules,2019,vol. 24,# 17,art. no. 3182]