Indolizine, 1-methoxy-2-methyl- (9CI) synthesis

Yield:610766-99-9 77.5%

Reaction Conditions:

Stage #1: 2-(methoxymethyl)pyridine;chloroacetonewith potassium carbonate;lithium bromide in acetonitrile;Heating / reflux;Chichibabin Reaction;
Stage #2: with potassium carbonate in water;acetonitrile;

Steps:

III

The compounds of formula II, when R₁ represents a radical -OCH₃ or a radical -OCH₂C₆H₅, are also prepared using the Tschitschibabin reaction according to the following synthesis schemes:; Preparation III Synthesis of 1-methoxy-2-methylindolizine This compound is obtained starting with 2-(methoxymethyl)pyridine and chloroacetone, using the Tschitschibabin reaction. The product is isolated in the form of a yellow oil which crystallizes in the freezer. Yield: 77.5% Mass spectrometry (ES+ mode): MH+=161.8

References:

US2005/203126,2005,A1 Location in patent:Page/Page column 10; 13