Iodoacetonitrile synthesis
- Product Name:Iodoacetonitrile
- CAS Number:624-75-9
- Molecular formula:C2H2IN
- Molecular Weight:166.95
590-17-0
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624-75-9
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Yield:624-75-9 100%
Reaction Conditions:
with sodium iodide in acetone
Steps:
7.2
Step 2. The method follows that of S5; 2, 6-piperidinedimethanol (3.80 g, 26.21 mmol), iodoacetonitrile (5.24 g, 31.45 mmol), Et3N (4. 38 mL, 31.45 mmol) and dry DMF (20 mL). Purification by flash chromatography using CH2CI2/CH30H (9: 1) as eluent afforded the title compound as a straw-coloured oil (2.5 g, 53 %). FAB MS, m/z (M+H) + 185. The iodoacetonitrile was prepared by the use of the Finkelstein reaction. BrCH2CN (3.77 g, 0.0314 mmol) was added dropwise to a stirred solution of Nal (4.71 g, 0.031 mmol) in acetone. Precipitation of NaBr occurred within a few minutes and indicated that exchange of the halides had taken place. Sodium bromide was filtered off, and the acetone was removed in vacuo. Crude yield (5.24 g, 100 %).
References:
SCHOOL OF PHARMACY, UNIVERSITY OF LONDON WO2005/61453, 2005, A1 Location in patent:Page/Page column 15
107-14-2
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624-75-9
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372-09-8
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624-75-9
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![[methyl(phenyl)amino]acetonitrile](/CAS/GIF/16728-83-9.gif)
16728-83-9
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74-88-4
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624-75-9
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98-04-4
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2265-93-2
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75-05-8
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624-75-9
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372-18-9
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