Levomefolic Acid synthesis

Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: sodium hydroxide; sodium tetrahydroborate; edetate disodium / water / 25 - 92 °C
1.2: 0 - 10 °C / pH 9
2.1: hydrogenchloride / water / 1 h / 5 - 30 °C / pH 3.2-3.4
3.1: water / 25 - 70 °C
4.1: water / 25 - 70 °C / Resolution of racemate
5.1: hydrogenchloride / water / 25 - 30 °C / pH 5 - 7.6

References:

WATSON LABORATORIES, INC.;BHANU, Manjunath, Narayan;SINHA, Chandrasekhar;AHER, Bhupesh;SONAR, Jitendra WO2013/25203, 2013, A1

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