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Folic acid

Description
Folic acid
Folic acid
CAS No.
59-30-3
Chemical Name:
Folic acid
Synonyms
PGA;Folan;folic;Aspol;FOLSAN;Folate;Folbal;Folsav;VM/PGA;PTEGLU
CBNumber:
CB5100903
Molecular Formula:
C19H19N7O6
Formula Weight:
441.4
MOL File:
59-30-3.mol

Folic acid Properties

Melting point:
250 °C
alpha 
20 º (c=1, 0.1N NaOH)
Boiling point:
552.35°C (rough estimate)
Density 
1.4704 (rough estimate)
refractive index 
1.6800 (estimate)
storage temp. 
2-8°C
solubility 
boiling water: soluble1%
form 
Crystalline Powder
pka
pKa 2.5 (Uncertain)
color 
Yellow to orange
Water Solubility 
1.6 mg/L (25 ºC)
Merck 
14,4221
BRN 
100781
Stability:
Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive.
InChIKey
OVBPIULPVIDEAO-LBPRGKRZSA-N
CAS DataBase Reference
59-30-3(CAS DataBase Reference)
NIST Chemistry Reference
Folic acid(59-30-3)
EPA Substance Registry System
L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro- 4-oxo-6-pteridinyl)methyl] amino]benzoyl]-(59-30-3)

SAFETY

Risk Statements  33-62-68
Safety Statements  24/25
WGK Germany  1
RTECS  LP5425000
8
TSCA  Yes
HS Code  29362900
Hazardous Substances Data 59-30-3(Hazardous Substances Data)

Folic acid price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F7876 Folic acid ≥97% 59-30-3 1g $16.9 2018-11-13 Buy
Sigma-Aldrich 1286005 Folic acid United States Pharmacopeia (USP) Reference Standard 59-30-3 500mg $357.7 2018-11-13 Buy
TCI Chemical F0043 Folic Acid Hydrate >98.0%(HPLC)(T) 59-30-3 25g $54 2018-11-22 Buy
Alfa Aesar J60833 Folic acid, crystalline 59-30-3 25g $59.6 2018-11-13 Buy
Alfa Aesar J60833 Folic acid, crystalline 59-30-3 100g $190 2018-11-13 Buy

Folic acid Chemical Properties,Uses,Production

Description

Folic acid (folate) is a kind of B-vitamin which is mainly present in the liver and kidney. It has various kinds of pharmacological and physiological effects. It is involved in amino acid metabolism, purine and pyrimidine synthesis, and is also essential for hematopoiesis and red blood cell generation. In women pregnancy, folate can effectively prevent neural tube defects in the baby. It plays important role in fertility through contributing to spermatogenesis. It can also reduce the incidence of heart disease, stroke and cancer. 
Folate deficiency may lead to various kinds of diseases including glossitis, diarrhea, depression, confusion, anemia, and fetal neural tube defectsand brain defects (during pregnancy). Other symptoms may include fatigue, gray hair, mouth sores, poor growth, and swollen tongue.

Chemical Properties

orange to yellow crystalline powder

Uses

A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.

Uses

hematopoietic vitamin

Uses

folic acid is generally used as an emollient. In vitro and in vivo skin studies now indicate its capacity to aid in DnA synthesis and repair, promote cellular turnover, reduce wrinkles, and promote skin firmness. There is some indication that folic acid may also protect DnA from uV-induced damage. Folic acid is a member of the vitamin B complex and is naturally occurring in leafy greens.

Uses

Literature tends to indicate that B vitamins cannot pass through the layers of the skin and, therefore, are of no value in the skin surface. Current experiments demonstrate, however, that vitamin B2 acts as a chemical reaction accelerator, enhancing the performance of tyrosine derivatives in suntan-accelerating preparations.

Uses

Folic Acid is a water-soluble b-complex vitamin that aids in the for- mation of red blood cells, prevents certain anemias, and is essential in normal metabolism. high-temperature processing affects its sta- bility. it is best stored at lower than room temperatures. it is also termed folacin. it is found in liver, nuts, and green vegetables.

Definition

ChEBI: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.

General Description

Odorless orange-yellow needles or platelets. Darkens and chars from approximately 482°F.

Air & Water Reactions

Insoluble in water. Aqueous solutions have pHs of 4.0-4.8.

Reactivity Profile

Acid solutions of Folic acid are sensitive to heat, but towards neutrality, stability progressively increases. Solutions are inactivated by ultraviolet light and alkaline solutions are sensitive to oxidation. Folic acid is also inactivated by light. Folic acid is incompatible with oxidizing agents, reducing agents and heavy metal ions.

Fire Hazard

Flash point data for Folic acid are not available; however, Folic acid is probably combustible.

Safety Profile

Poison by intraperitoneal and intravenous routes. Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

If paper chromatography indicates impurities, then recrystallise it from hot H2O or from dilute acid [Walker et al. J Am Chem Soc 70 19 1948]. Impurities may be removed by repeated extraction with n-BuOH of a neutral aqueous solution of folic acid (by suspending in H2O and adding N NaOH dropwise till the solid dissolves, then adjusting the pH to ~7.0-7.5) followed by precipitation with acid, filtration, or better collected by centrifugation and recrystallised form hot H2O. [Blakley Biochem J 65 331 1975, Kalifa et al. Helv Chim Acta 6 1 2739 1978.] Chromatography on cellulose followed by filtration through charcoal has also been used to obtain pure acid. [Sakami & Knowles Science 129 274 1959.] UV: max 247 and 296nm ( 12,800 and 18,700) in H2O pH 1.0; 282 and 346nm ( 27.600 and 7,200) in H2O pH 7.0; 256, 284 and 366nm ( 24600, 24,500 and 86,00) in H2O pH 13 [Rabinowitz in The Enzymes (Boyer et al. Eds), 2 185 1960]. [Beilstein 26 III/IV 3944.]

Folic acid Preparation Products And Raw materials

Raw materials

Preparation Products


Folic acid Suppliers

Global( 477)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
025-84209270 wgp@nanjing-pharmaceutical.com CHINA 117 55
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 277 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 fandachem@gmail.com CHINA 2097 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 894 55
Accela ChemBio Inc.
+86 (021)-5079 5510
+86 (021)-5079 5055 info@accelachem.com CHINA 12156 58

View Lastest Price from Folic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Folic acid
59-30-3
US $2.00 / KG 1KG 99% customsie career henan chemical co

Folic acid Spectrum


59-30-3(Folic acid)Related Search:


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