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ChemicalBook CAS DataBase List MDL-29951
130798-51-5

MDL-29951 synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 1.) aq. HCl, sodium nitrite, 2.) sodium acetate / 1.) from 0 deg C to 5 deg C, 2.) water, from 0 deg C to RT, 75 min
2: H2SO4 / 24 h / Heating
3: p-toluenesulfonic acid / toluene / 2 h / Heating
4: 84 percent / aq. LiOH / tetrahydrofuran / Ambient temperature

References:

Salituro, Francesco G.;Harrison, Boyd L.;Baron, Bruce M.;Nyce, Philip L.;Stewart, Kenneth T.;et al. [Journal of Medicinal Chemistry,1992,vol. 35,# 10,p. 1791 - 1799]