MELITTIN synthesis
- Product Name:MELITTIN
- CAS Number:20449-79-0
- Molecular formula:C131H229N39O31
- Molecular Weight:2846.46
29022-11-5
492 suppliers
$5.00/1g
68858-20-8
498 suppliers
$8.00/1g
35661-60-0
522 suppliers
$5.00/1g
35661-39-3
499 suppliers
$5.00/1g
71989-31-6
481 suppliers
$6.00/5g
71989-23-6
440 suppliers
$6.00/5g
35737-15-6
366 suppliers
$6.00/5g
73731-37-0
295 suppliers
$13.00/1g
105047-45-8
217 suppliers
$8.00/1g
73724-45-5
330 suppliers
$5.00/1g
71989-20-3
338 suppliers
$6.00/5g
91000-69-0
213 suppliers
$6.00/1g
20449-79-0
171 suppliers
$67.70/1mg
Yield:-
Reaction Conditions:
Stage #1:N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine with 1-hydroxy-7-aza-benzotriazole;O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one;N,N-dimethyl-formamide
Stage #2: with piperidine in N,N-dimethyl-formamide for 0.55 h;
Stage #3:N-(fluoren-9-ylmethoxycarbonyl)glycine;Fmoc-Val-OH;Fmoc-Leu-OH;N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine;Fmoc-Pro-OH;Fmoc-Ile-OH;Fmoc-Trp-OH;Fmoc-Thr-OH;Fmoc-Lys-OH;N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine;Fmoc-L-Arg-OHFurther stages;
References:
Sahariah, Priyanka;Benediktssdóttir, Berglind E.;Hjálmarsdóttir, Martha Á.;Sigurjonsson, Olafur E.;Sørensen, Kasper K.;Thygesen, Mikkel B.;Jensen, Knud J.;Másson, Már [Biomacromolecules,2015,vol. 16,# 5,p. 1449 - 1460]