METHYL 2-(1,2-BENZISOXAZOL-3-YL)ACETATE synthesis

15synthesis methods

Product Name:METHYL 2-(1,2-BENZISOXAZOL-3-YL)ACETATE
CAS Number:59899-89-7
Molecular formula:C10H9NO3
Molecular Weight:191.18

4865-84-3
196 suppliers
$14.14/1gm:

18107-18-1
210 suppliers
$33.00/5g

59899-89-7
33 suppliers
$45.00/50mg

Yield:59899-89-7 99%

Reaction Conditions:

in methanol;dichloromethane at 0; for 1 h;

Steps:

30a

Trimethylsilydiazomethane (9.7 mL, 19.40 mmol) is added dropwise to benzo[d]isoxazol-3-yl-acetic acid (3.3 g, 17.64 mmol) in DCM/MeOH 11:1(22 mLI2 mL) at 0°C and stirring is continued for 1 h at 0CC. Volatiles are evaporated to give the title compound (3.3 g, 99%)U PLC-MS (Method 2): R = 0.88 mmMS (ESI pos): mlz = 192 (M+H)

References:

WO2014/184275,2014,A1 Location in patent:Page/Page column 199; 200

67-56-1 Synthesis