Methyl 2-(2-methoxyphenyl)-2-methylpropanoate synthesis
4synthesis methods
- Product Name:Methyl 2-(2-methoxyphenyl)-2-methylpropanoate
- CAS Number:40801-03-4
- Molecular formula:C12H16O3
- Molecular Weight:208.26
Yield:40801-03-4 96%
Reaction Conditions:
Stage #1: 2-bromo-2-methylpropionic acid methyl esterwith zinc in tetrahydrofuran at 20; for 0.5 h;Inert atmosphere;Sealed tube;
Stage #2: 2-bromoanisolewith di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I) in tetrahydrofuran at 20; for 4 h;Inert atmosphere;Sealed tube;
References:
Hama, Takuo;Ge, Shaozhong;Hartwig, John F. [Journal of Organic Chemistry,2013,vol. 78,# 17,p. 8250 - 8266]
