Methyl 2-(4-Amino-2-fluorophenyl)acetate synthesis
- Product Name:Methyl 2-(4-Amino-2-fluorophenyl)acetate
- CAS Number:192650-54-7
- Molecular formula:C9H10FNO2
- Molecular Weight:183.18
337529-74-5
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Yield:192650-54-7 86%
Reaction Conditions:
with palladium on activated charcoal;hydrogen in ethyl acetate; for 5 h;
Steps:
76.2 Step 2. Preparation of methyl 2-(4-amino-2-fluorophenyl)acetate
To a 50 ml round bottom flask, were added methyl 2-(2-fluoro-4-nitrophenyl)acetate (3.8 g, 0.018 mol) and ethyl acetate (30 ml). To the same flask, 10 percent palladium on activated carbon (0.5 g) was added. The reaction mixture was stirred under hydrogen gas (using bladder) atmosphere for 5 h. The reaction mixture was filtered through a pad of celite. The filtrate was evaporated under reduced pressure to get the title compound (2.8 g, 86%), MS (+) ES: 184 (M+H)+.
References:
WO2019/213470,2019,A1 Location in patent:Page/Page column 97; 98
315228-19-4
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