methyl 2-bromo-5-(chlorosulfonyl)benzoate synthesis
- Product Name:methyl 2-bromo-5-(chlorosulfonyl)benzoate
- CAS Number:924867-87-8
- Molecular formula:C8H6BrClO4S
- Molecular Weight:313.55
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Yield:924867-87-8 100%
Reaction Conditions:
with dichlorosulfoxide at 0 - 80; for 3 h;
Steps:
57.1 Step 1: Synthesis of methyl 2-bromo-5-(chlorosulfonyl)benzoate (57b).
To a solution of 57a (6 g, 30 mmol) in MeOH (60 mL), SOCl2(10.7 g, 90 mmol) was slowly added at 0 °C. And then the resulting mixture was stirred at 80 °C for 3 h. Concentrated and the residue was concentrated and purified by FCC (PE: EA = 5%) to afford the product as colorless oil (6.5 g).Yield: 100%. ESI-MS, m/z 214.8 (M+H)+.
References:
WO2022/115417,2022,A1 Location in patent:Paragraph 000247
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3285-31-2
30 suppliers
$292.00/250mg
924867-87-8
17 suppliers
inquiry