METHYL 2-PYRIDYLACETATE synthesis
- Product Name:METHYL 2-PYRIDYLACETATE
- CAS Number:1658-42-0
- Molecular formula:C8H9NO2
- Molecular Weight:151.16
67-56-1
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16179-97-8
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1658-42-0
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Yield:1658-42-0 100%
Reaction Conditions:
Stage #1: methanol;pyridin-2-yl acetic acid hydrochloridewith chloro-trimethyl-silane at 0 - 20;Inert atmosphere;
Stage #2: with sodium hydrogencarbonate in water;
Steps:
Synthesis of ligand L9
S2 was prepared analogously to a published procedure.13 2.00 g S1 (11.5 mmol, 1.00 equiv.) and 14 mL MeOH were added to a round-bottom flask. The solution was cooled to 0 °C, and 2.90 mL TMSCl (23.0 mmol, 2.00 equiv.) were added dropwise. The mixture was allowed to warm to room temperature and stirred overnight. The solvent was then removed in vacuo, ant the remaining solid was treated slowly with sat. aq. NaHCO3 (40 mL). The aqueous solution was extracted with CH2Cl2 (4 x 40 mL), and the combined organic extracts were dried over Na2SO4, filtered, and the solvent was removed in vacuo. The crude product (S2) was isolated as a clear oil (1.73 g, 11.47 mmol, quant.). The spectral data of the compound were compared with the published ones.13
References:
Podhajsky, Susanne M.;Iwai, Yasumasa;Cook-Sneathen, Amanda;Sigman, Matthew S. [Tetrahedron,2011,vol. 67,# 24,p. 4435 - 4441] Location in patent:supporting information; experimental part
16179-97-8
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$14.00/1g
1658-42-0
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67-56-1
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13115-43-0
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1658-42-0
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3731-51-9
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67-56-1
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201230-82-2
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1658-42-0
181 suppliers
$11.00/1g