Methyl 3-[(3-pyridinylmethyl)amino]propanoate synthesis
1synthesis methods
- Product Name:Methyl 3-[(3-pyridinylmethyl)amino]propanoate
- CAS Number:33710-20-2
- Molecular formula:C10H14N2O2
- Molecular Weight:194.23
Yield:33710-20-2 82.5%
Reaction Conditions:
in methanol;
Steps:
27.1 EXAMPLE 27
(1) 3-Pyridylmethylamine (10.81 g) is dissolved in methanol (50 ml), and thereto is added dropwise methyl acrylate (8.60 g) under ice-cooling. The mixture is stirred at room temperature for 18 hours. The mixture is distilled to remove the solvent, and then the residue is distilled under reduced pressure to give methyl 3-(3-pyridylmethylamino)propionate (16.02 g, 82.5%), b.p. 119°-120° C./0.4 mmHg.
References:
US4663319,1987,A