Methyl 3-aMino-2-phenylpropanoate hydrochloride synthesis
- Product Name:Methyl 3-aMino-2-phenylpropanoate hydrochloride
- CAS Number:91012-17-8
- Molecular formula:C10H14ClNO2
- Molecular Weight:215.6767
67-56-1
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Yield:91012-17-8 97%
Reaction Conditions:
with oxalyl dichloride at 20; for 120 h;
Steps:
75A Example 75A (+/-)-Methyl 3-amino-2-phenylpropanoate hydrochloride (Racemate)
[0674] At RT, oxalyl chloride (740 μl, 8.5 mmol) was slowly added to a suspension of (+/-)-3-amino-2-phenylpropanoic acid (700 mg, 4.24 mmol) in methanol (10 ml), and the mixture was stirred at RT for 5 days. Then the mixture was concentrated. Repeatedly, dichloromethane was added to the residue and the mixture was re-concentrated. Subsequently, the residue was dried under reduced pressure. This gave 933 mg (95% purity, 97% of theory) of the title compound. [0675] LC-MS (Method 4): Rt=0.93 min; MS (ESIpos): m/z=180 [M+H]+ [0676] 1H-NMR (400 MHz, DMSO-d6): δ [ppm]=8.20 (br. s, 3H), 7.63-7.10 (m, 5H), 4.11 (dd, 1H), 3.64 (s, 3H), 3.46 (dd, 1H), 3.07 (dd, H).
References:
US2020/31775,2020,A1 Location in patent:Paragraph 0673-0676
30698-30-7
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