methyl 3-amino-3-thioxopropanoate synthesis
- Product Name:methyl 3-amino-3-thioxopropanoate
- CAS Number:689-09-8
- Molecular formula:C4H7NO2S
- Molecular Weight:133.17
105-34-0
456 suppliers
$5.00/25g
689-09-8
50 suppliers
$65.00/100mg
Yield:689-09-8 95%
Reaction Conditions:
with sodium hydrogen sulphide;copper chloride (II) in methanol at 70; for 4 h;
Steps:
2 Example 2
The present embodiment provides a method for synthesizing thioamide carboxylate, comprising the following steps: weighing 1 equivalent of methyl cyanoacetate into a reaction flask,Add 7 times the volume of methanol of ethyl cyanoacetate mass,Add 3.5 equivalents of sodium hydrosulfide and 0.5 equivalents of copper chloride with methyl cyanoacetate;Slowly raise the temperature to 70°C,The temperature was maintained and stirred for 4 hours; after the reaction was completed, the heating was terminated, and the solvent was removed by concentration under reduced pressure.Add 1 times the volume of ethanol saturated ammonium chloride solution to quench, use 1 times the volume of ethanol to extract with ethyl acetate; the organic phase is concentrated under reduced pressure to obtain a brown oily liquid. Rectification under reduced pressure at 115° C., collecting fractions to obtain a colorless oily liquid, which is methyl thiopropionamide, with a yield of 95%.
References:
CN114516824,2022,A Location in patent:Paragraph 0066-0068
298-06-6
169 suppliers
$62.50/5G
105-34-0
456 suppliers
$5.00/25g
689-09-8
50 suppliers
$65.00/100mg