Methyl 3-amino-6-chloropyrazine-2-carboxylate synthesis
- Product Name:Methyl 3-amino-6-chloropyrazine-2-carboxylate
- CAS Number:1458-03-3
- Molecular formula:C6H6ClN3O2
- Molecular Weight:187.58
16298-03-6
1458-03-3
Methyl 3-aminopyrazine-2-carboxylate (100 g, 0.653 mol) was used as starting material, which was co-dissolved with N-chlorosuccinimide (NCS, 87.2 g, 0.653 mol) in acetonitrile (500 mL) in a 1 L three-neck flask. The reaction mixture was heated to 82 °C and the reaction was maintained at this temperature with stirring for 12 h to ensure complete reaction. Upon completion of the reaction, the acetonitrile solvent was removed by distillation under reduced pressure. The resulting crude product was purified by recrystallization using mixed petroleum ether/ethyl acetate solvent, and the final bright green crystalline target product, methyl 3-amino-6-chloropyrazine-2-carboxylate (112.7 g, 92% yield) was obtained.
16298-03-6
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1458-03-3
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$10.00/100mg
Yield: 98.1%
Reaction Conditions:
with N-chloro-succinimide in N,N-dimethyl-formamide at 80; for 24 h;
Steps:
1.1
(1) Dissolve 60g compound A in 300mL DMF, add 30g NCS, heat to 80°C, stir the reaction for 24h, TLC test, the raw material reaction is complete, the solvent is removed by rotary evaporation under reduced pressure, the remaining solid is added to 500mL water, stirred for 20min, filtered, The filter cake was washed with water, and the solid was vacuum-dried to obtain 72.1 g of brown solid to obtain compound B with a purity of 98.8% and a yield of 98.1%;
References:
CN113135862, 2021, A Location in patent:Paragraph 0005; 0013-0015
17149-35-8
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1458-03-3
123 suppliers
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28643-16-5
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