2-Amino-5-chloropyrazine synthesis
- Product Name:2-Amino-5-chloropyrazine
- CAS Number:33332-29-5
- Molecular formula:C4H4ClN3
- Molecular Weight:129.55
5049-61-6
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33332-29-5
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$14.00/1g
Yield:33332-29-5 80%
Reaction Conditions:
with N-chloro-N-methoxy-4-methylbenzenesulfonamide in acetonitrile at 40; for 4 h;Reagent/catalyst;Temperature;
Steps:
Preparation of 2-amino-5-chloropyrazine (17)
Method B. To a suspension of 2-aminopyrazine (3 g, 31.6 mmol) in acetonitrile (50 mL) was added N-chloro-N-methoxy-4-methylbenzenesulfonamide (TSA, 8.2 g,34.7 mmol) in batches at room temperature. The reaction mixture was heated at 40 °C for 4 h. Subsequently, the solvent was evaporated in vacuum and the residue was partitioned between ethyl acetate (50 mL) and saturated aqueous Na2CO3solution (20 mL). The organic layer was dried over anhydrous Na2SO4,decolorized with activated charcoal (0.8 g), and concentrated. The crude product containing ~ 5% dichlorinated impurity judged by TLC was purified by chromatography on silica gel eluting with PE/EA (10:1-2:1) to give a light-yellow solid (3.3 g, yield 80%).
References:
Guo, Qi;Xu, Mingshuo;Guo, Shuang;Zhu, Fuqiang;Xie, Yuanchao;Shen, Jingshan [Chemical Papers,2019,vol. 73,# 5,p. 1043 - 1051]
5049-61-6
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6863-73-6
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33332-29-5
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$14.00/1g
873-42-7
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1458-03-3
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33332-29-5
259 suppliers
$14.00/1g
5049-61-6
445 suppliers
$8.00/10g
33332-29-5
259 suppliers
$14.00/1g
873-42-7
144 suppliers
$30.00/1g
6863-77-0
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6863-73-6
219 suppliers
$10.00/5g
33332-29-5
259 suppliers
$14.00/1g
33332-28-4
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$9.00/1g