Methyl 3-formyl-5-methylbenzoate synthesis
- Product Name:Methyl 3-formyl-5-methylbenzoate
- CAS Number:1205514-72-2
- Molecular formula:C10H10O3
- Molecular Weight:178.18
105578-30-1
3 suppliers
inquiry
1205514-72-2
19 suppliers
inquiry
Yield:1205514-72-2 84%
Reaction Conditions:
with pyridinium chlorochromate in dichloromethane at 20; for 2 h;Celite;
Steps:
10; 17
3-Formyl-5-meihylbenzoic acid methyl ester(3); To a stirred soiution of 3-hydroxymethy[-5-methylbenzoic acid methy. ester(14 4g, δOmmol) in dichloromethane(160ml), were added py?dimum chlorochromate(25 86g, 120mmol) and ceiιte(30g) After stirring for 2hr at room temperature, the mixture was diluted with ether and filtered through a plug of silica gel The plug was washed with ether The combined filtrate was evaporated in vacuo and the residue was pu?fjed by silica gel column chromatography(eiuent, ether hexane(1 9)) to give 12g(84%) of the title compound as a white solid m p 71-730C 1H-NMR(200MHz, CDCl3) δ 2 49(3H, s), 3 96(3H, s), 7 89(1 H, S)1 8 12(1 H, s), 8 32(1 H, s), 10 04(1H, s)
References:
WO2010/9047,2010,A1 Location in patent:Page/Page column 75
25081-39-4
105 suppliers
$6.00/250mg
1205514-72-2
19 suppliers
inquiry