Methyl 4-(3,4-dichlorophenyl)-4-oxobutanoate synthesis
- Product Name:Methyl 4-(3,4-dichlorophenyl)-4-oxobutanoate
- CAS Number:95652-74-7
- Molecular formula:C11H10Cl2O3
- Molecular Weight:261.1
50597-19-8
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74-88-4
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95652-74-7
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Yield:95652-74-7 100%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 1 h;
Steps:
methyl 4-(3,4-dichlorophenyl)-4-oxobutanoate
4-(3,4-dichlorophenyl)-4-oxobutanoic acid (3.19 g, 13 mmol, 1 Eq.) was dissolved in dimethylformamide (10 mL). Potassium carbonate (2.34 g, 17 mmol, 1.3 Eq.) was added and the mixtureswas stirred until it turns turbid. Then, iodomethane (1.37 mL, 22 mmol, 1.7 Eq.) was added andthe mixture was stirred for 1 h at room temperature. The product was extracted with ethylacetate(100 mL) and washed with a mixture of saturated sodium carbonate solution and saturatedsodium chloride solution (300 mL, 1:1). The organic solvent was removed in vacuo and theproduct was purified by chromatography (isco Combiflash, 24 g column, silica gel,dichloromethane/methanol 1-10 % gradient).Yield: 3.39 g (13 mmol, 100 %) of an orange solid.
References:
Fischer, Patrick D.;Papadopoulos, Evangelos;Dempersmier, Jon M.;Wang, Zi-Fu;Nowak, Rados?aw P.;Donovan, Katherine A.;Kalabathula, Joann;Gorgulla, Christoph;Junghanns, Pierre P.M.;Kabha, Eihab;Dimitrakakis, Nikolaos;Petrov, Ognyan I.;Mitsiades, Constantine;Ducho, Christian;Gelev, Vladimir;Fischer, Eric S.;Wagner, Gerhard;Arthanari, Haribabu [European Journal of Medicinal Chemistry,2021,vol. 219,art. no. 113435] Location in patent:supporting information
95652-75-8
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95652-74-7
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6287-38-3
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95652-74-7
8 suppliers
$339.00/1g
50597-19-8
36 suppliers
$257.00/1g
95652-74-7
8 suppliers
$339.00/1g