Methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate synthesis
- Product Name:Methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate
- CAS Number:61032-41-5
- Molecular formula:C16H15NO6
- Molecular Weight:317.29
67-56-1
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60547-92-4
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61032-41-5
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Yield: 80%
Reaction Conditions:
with thionyl chloride at 60; for 96 h;Inert atmosphere;
Steps:
6 4-Benzyloxy-3-methoxy-2-nitrobenzoic acid methyl ester (24)
Under argon, at room temperature, to a suspension of (19) (4.0 g, 131 mmol) in absolute methanol (100 mL) was added dropwise thionyl chloride (1.9 mL, 262 mmol). The resulting mixture was stirred at 60°C for 96 hrs then concentrated under reduced pressure until few volume. The residue was allowed to crystallize at -20°C and the solid was collected by filtration affording 4-benzyloxy- (0294) 3-methoxy-2-nitrobenzoic acid methyl ester (24) (3.36 g, 80%) as a white crystal. LCMS CieHisNOe Rt = 6.862 min, ESI+ m/z = 318.9 (M+H), 285.9 (M-OMe).
References:
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE);INSTITUT JEAN PAOLI & IRENE CALMETTES;AIX-MARSEILLE UNIVERSITÉ;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) WO2021/74392, 2021, A1 Location in patent:Page/Page column 44-45
56441-97-5
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61032-41-5
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$9.00/1g
56441-97-5
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108-24-7
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61032-41-5
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3943-74-6
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100-39-0
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61032-41-5
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1486-53-9
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$8.00/250mg
61032-41-5
83 suppliers
$9.00/1g