Methyl 6-chloro-2-Methylnicotinate synthesis
- Product Name:Methyl 6-chloro-2-Methylnicotinate
- CAS Number:851759-19-8
- Molecular formula:C8H8ClNO2
- Molecular Weight:185.61
223788-08-7
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$140.00/250mg
851759-19-8
55 suppliers
$145.00/250mg
Yield: 98.7%
Reaction Conditions:
with trichlorophosphate at 100; for 4 h;
Steps:
3 Step 3: Preparation of methyl 2-methyl-6-chloronicotinate
Add 500mL reaction flasks one by one6-hydroxy-2-methylnicotinic acid methyl ester (140g, 0.84mol),300 mL of phosphorus oxychloride,The reaction was heated to 100 ° C for 4 hours.Concentrated under reduced pressure,The residue was slowly poured into 1000 mL of ice water,A large amount of gray-black solid precipitated,Stir for 1 hour,Suction filtration,The cake was air-dried at room temperature.153 g of methyl 6-chloro-2-methylnicotinate was obtained, 98.7%.
References:
Shiyao Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.;Zhang Yan;Wei Miaomiao;Zhang Xuejiao;Mi Guorui;An Hui;Wei Bing;Guo Qian CN110878096, 2020, A Location in patent:Paragraph 0166; 0167; 0172; 0173
1033809-42-5
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851759-19-8
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$145.00/250mg
177785-14-7
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$185.00/100mg
67-56-1
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$7.29/5ml-f
137129-98-7
125 suppliers
$14.00/100mg
851759-19-8
55 suppliers
$145.00/250mg
1033809-42-5
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851759-19-8
55 suppliers
$145.00/250mg
65719-09-7
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$21.00/1g
851759-19-8
55 suppliers
$145.00/250mg