Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate synthesis
- Product Name:Methyl 6-oxo-1,6-dihydropyridine-2-carboxylate
- CAS Number:30062-34-1
- Molecular formula:C7H7NO3
- Molecular Weight:153.14
67-56-1
19621-92-2
30062-34-1
Step 1: Synthesis of methyl 6-hydroxypyridine-2-carboxylate. 6-Hydroxypyridine-2-carboxylic acid (13.0 g, 93.5 mmol) was dissolved in methanol (150 mL) at room temperature and a dioxane solution of 4N HCl (10 mL) was slowly added. The reaction mixture was stirred at room temperature for 48 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to afford methyl 6-hydroxypyridine-2-carboxylate (13 g, 90% yield) as a white solid.
67-56-1
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19621-92-2
245 suppliers
$7.00/1g
30062-34-1
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Yield: 90%
Reaction Conditions:
with thionyl chloride for 14 h;Heating / reflux;
References:
CHONG KUN DANG PHARMACEUTICAL CORP. WO2004/37808, 2004, A1 Location in patent:Page 19-20
19621-92-2
245 suppliers
$7.00/1g
30062-34-1
78 suppliers
$15.00/250mg