methyl triallyl acetate synthesis
- Product Name:methyl triallyl acetate
- CAS Number:824413-84-5
- Molecular formula:C12H18O2
- Molecular Weight:194.27
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Yield:824413-84-5 80%
Reaction Conditions:
Stage #1: methyl 2-(prop-2-enyl)pent-4-enoatewith lithium diisopropyl amide in tetrahydrofuran at -78; for 0.5 h;Inert atmosphere;
Stage #2: allyl bromidewith N,N,N,N,N,N-hexamethylphosphoric triamide in tetrahydrofuran; for 2 h;Inert atmosphere;
Steps:
1.5
Step 5) Under N2 protection, In 500 ml of anhydrous tetrahydrofuran 225 ml of a 2 M solution of lithium diisopropylamide in tetrahydrofuran, Then cooled to _78 ° C, Then 70 g of compound 4 was added dropwise, After half a hour of reaction, a mixture of 60 g of 3-bromopropene and 90 g of hexamethylphosphoric triamide was added dropwise, and then the reaction was carried out for two hours, After completion of the reaction 50 ml of saturated ammonium chloride solution quenched, Heating up to room temperature, After spin-out of tetrahydrofuran, 200 ml of water was added, Then extracted twice with 500 ml of methyl tert-butyl ether, The organic phase was dried over anhydrous sodium sulfate overnight, After removal of the solvent, distillation under reduced pressure gave 69 g of the title compound 5 in 80% yield,
References:
CN104151161,2016,B Location in patent:Paragraph 0016; 0021
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