MonoMethyl auristatin E synthesis
- Product Name:MonoMethyl auristatin E
- CAS Number:474645-27-7
- Molecular formula:C39H67N5O7
- Molecular Weight:717.98
120205-50-7
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474645-27-7
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Yield:-
Steps:
Multi-step reaction with 6 steps
1: caesium carbonate / 1,4-dioxane; water / 0.33 h
2: dichloromethane / 0.25 h / 20 °C
3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C
4: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 0.5 h / 20 °C
5: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C
6: trifluoroacetic acid / dichloromethane
References:
US2015/23989,2015,A1
149606-97-3
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177423-00-6
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474645-25-5
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474645-27-7
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