ChemicalBook CAS DataBase List Mustard gas

Mustard gas synthesis

7synthesis methods

Product Name:Mustard gas
CAS Number:505-60-2
Molecular formula:C4H8Cl2S
Molecular Weight:159.08

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Yield:505-60-2 51%

Reaction Conditions:

with thionyl chloride at 80; for 2 h;Cooling with ice;

Steps:

I.2.15.2 Step 2:
Preparation of bis(2-chloroethyl)sulfane (4)

Thionyl chloride (1.781 mL) was added to 2,2'-thiobis(ethan-1-ol) (3) (2.0 g, 0.041 mol) under ice cold condition.
The resulting mixture was stirred at 80° C. for 2 h.
The progress of the reaction was monitored by TLC.
The crude was concentrated under reduced pressure to afford the title compound as brown colour liquid.
Yield (1.5 g, 51%).
1H-NMR (400 MHz, DMSO-d6): δ 3.77 (t, J=7.44 Hz, 4H), and 2.94 (t, J=7.32 Hz, 4H).

References:

ITEOS THERAPEUTICS S.A.;CROSIGNANI, Stefano US2020/102319, 2020, A1 Location in patent:Paragraph 1743; 1745

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