ChemicalBook CAS DataBase List N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID

N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID synthesis

14synthesis methods

Product Name:N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID
CAS Number:67990-66-3
Molecular formula:C13H11ClN2O2
Molecular Weight:262.69

60091-87-4 Synthesis

2-[(4-CHLORO-2-NITROPHENYL)AMINO]-BENZOIC ACID

60091-87-4
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N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID

67990-66-3
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$38.00/250mg

Yield: 100%

Reaction Conditions:

with hydrogen;platinum on sulfide coal in ethyl acetate under 1500.15 Torr; for 5 h;

Steps:

78
2-[(2-Amino-4-chlorophenyl)amino]benzoic acid (Structure 71 of scheme XVI) To a solution of 2-f (4-chloro-2-nitrophenvl) aminolbenzoic acid (12.8 g, 43.7 mmol) in ethyl acetate (300 mL) was added platinum on sulfide coal 5%. The reaction mixture was hydrogenated at 2 bar for 5 h. After filtration through dicalite, washing with ethyl acetate and removal of the solvent under reduced pressure the title compound (11.8 g, 100 %) was obtained.

References:

AKZO NOBEL N.V. WO2003/84963, 2003, A1 Location in patent:Page/Page column 18; 65