N-(2-chloro-5-methoxyphenyl)acetamide synthesis
- Product Name:N-(2-chloro-5-methoxyphenyl)acetamide
- CAS Number:51488-87-0
- Molecular formula:C9H10ClNO2
- Molecular Weight:199.63
Yield:51488-87-0 97%
Reaction Conditions:
in water at 20;Sonication;Heating;
Steps:
/V-(2-chloro-5-methoxyphenyl)acetamide (68)
Compound 67 (4 g, 25.38 mmol) was suspended in 40 mL DI water, to which Acetic anhydride (9.6 mL, 102 mmol) was added dropwise. The reaction mixture was placed in an ultrasonication bath for 1 min, then was stirred in a water bath (50° C) for 10 min. The resulting solution was stirred overnight at rt. After which, the solid was collected via vacuum filtration and washed with small portions of DI water. The product was left in the funnel and air dried overnight to afford compound 68 (4.91 g, 97%) as a white solid, which was used for the next step without further purification.
References:
WO2020/23911,2020,A2 Location in patent:Page/Page column 85
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