N-(2-PyridinylMethyl)-MethanesulfonaMide synthesis
1synthesis methods
- Product Name:N-(2-PyridinylMethyl)-MethanesulfonaMide
- CAS Number:74351-44-3
- Molecular formula:C7H10N2O2S
- Molecular Weight:186.23
Yield:74351-44-3 61%
Reaction Conditions:
with pyridine in dichloromethane at 20; for 12 h;
Steps:
1.1 [Step 1] N-(pyridin-2-ylmethyl)methanesulfonamide
A solution of pyridin-2-ylmethanamine (1.000 g, 9.247 mmol), pyridine (0.821 mL, 10. 172 mmol) and methanesulfonyl chloride (0.865 mL, 11.097 mmol) in dichloromethane (10 mL) was stirred at the room temperature for 12 hr. The precipitates were collected by filtration, washed by dichloromethane, and dried to give N(pyridin-2-ylmethyl)methanesulfonamide as brown solid (1.050 g, 61.0 %).
References:
WO2017/18803,2017,A1 Location in patent:Paragraph 304; 305; 306; 307