N-(3-ACETYL-PHENYL)-2-CHLORO-ACETAMIDE synthesis

Yield:42865-69-0 92%

Reaction Conditions:

with triethylamine in dichloromethane at 20; for 0.5 h;

Steps:

Synthetic procedure for N-(3-acetylphenyl)-2-chloroacetamide (3)

To the solution (1 mmol) of 3-aminoacetopheneone (1) and(1 mmol) of 2-chloroacetyl chloride (2) in TEA (3 ml) followedby DCM (10 ml), the reaction mixture was stirred at roomtemperature. After completing the reaction monitored byTLC, the solid was washed with ethanol-water to get crudeproducts N-(3-acetylphenyl)-2-chloroacetamide 3 (92%) yield. Colourless solid; m.p. 186-182 °C; 1H NMR(300 MHz CDCl3): δ 2.61 (s, 3H), 4.21 (s, 2H), 7.44 (t,1H, J = 7.8 Hz), 7.74 (d, 1H, J = 7.8 Hz), 7.90 (d, 1H, J =7.8 Hz), 8.05 (s, 1H), 8.48 (s, 1H). ESI-MS (M+ +1)calculated m/z 211.64 Found 212.04 Anal. Calcd for:C10H10ClNO2: C, 56.75; H, 4.76; N, 6.62% found: C,56.24; H, 4.72; N, 6.60%.

References:

Lakshmanan, Sivalingam;Govindaraj, Dharman;Mahalakshmi;Thirumurugan;Ramalakshmi;Antony, S. Arul [Structural Chemistry,2021,vol. 32,# 4,p. 1597 - 1609]