N-(3-FLUOROPHENYL)(PHENYLAMINO)FORMAMIDE synthesis
- Product Name:N-(3-FLUOROPHENYL)(PHENYLAMINO)FORMAMIDE
- CAS Number:350-79-8
- Molecular formula:C13H11FN2O
- Molecular Weight:230.24
Yield:350-79-8 67%
Reaction Conditions:
with sodium acetate in methanol at 60; for 2 h;
Steps:
11.2 Method 2 was prepared as follows
a magnetic, 3-phenyl-1,4,2-dioxazol-5-one (0.3 mmol) was added to a 10 mL round bottom flask in air. Sodium acetate (0.3 mmol) and methanol (1 mL), A further substituted amine (0.3 mmol) was added under stirring. Then, the rubber stopper was stoppered and heated and stirred in an oil bath at 60 ° C for 2 hours. After completion of the reaction, petroleum ether/ethyl acetate was used as a mobile phase, and the product was purified by flash silica gel column chromatography.
References:
CN109776244,2019,A Location in patent:Paragraph 0064-0065; 0067-0068
