N-(4-BROMO-PHENYL)-GUANIDINE synthesis
- Product Name:N-(4-BROMO-PHENYL)-GUANIDINE
- CAS Number:67453-81-0
- Molecular formula:C7H8BrN3
- Molecular Weight:214.06
Yield:67453-81-0 60%
Reaction Conditions:
Stage #1: carbodiimide;4-bromo-anilinewith hydrogenchloride in ethanol;water; for 1.5 h;Reflux;
Stage #2: with potassium carbonate in water;
Steps:
38.f
Example 38f l-(4-Bromophenyl)guanidine Hydrochloric acid (1.503 mL, 9.07 mmol) was added to 4-bromoaniline (2 g, 11.63 mmol) and carbodiimide (0.538 g, 12.79 mmol) in ethanol (10 mL) heated to reflux for 90 min. The solvent was removed under reduced pressure and potassium carbonate (0.964 g, 6.98 mmol) in water (10.00 mL) was added. Crystals were filtered off and washed with several portions of DCM to give the title compound (1.9 g, 60 %). MS (ES+) m/z 214 (M+H)+
References:
WO2010/53438,2010,A1 Location in patent:Page/Page column 91
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