N-(4-Chlorophenyl)-3-nitrobenzenemethanimine synthesis
- Product Name:N-(4-Chlorophenyl)-3-nitrobenzenemethanimine
- CAS Number:10480-25-8
- Molecular formula:C13H9ClN2O2
- Molecular Weight:260.68
Yield:10480-25-8 92%
Reaction Conditions:
in ethanol; for 3 h;Reflux;
Steps:
37
Example 372- [3 - (6-Chloro-3 ,3 -dimethyl- 1 ,2,3 ,4-tetrahydro-quinolin-2-yl) -phenylamino] -2- methyl-propionic acidA mixture of 4-chloro-phenylamine (6.4 g, 50 mmol) and 3-nitro-benzaldehyde (8.31 g, 55 mmol) in ethanol (100 mL) was prepared. The reaction mixture was heated to reflux for 3 h. Then the reaction mixture cooled to room temperature. The solvent was removed in vacuo and the residue was washed with ether to afford (4-chloro-phenyl)-(3-nitro- benzylidene)-amine (12 g, 92%) as a light yellow oil: LC/MS m/e calcd forCi3H9ClN202(M+H)+: 261.68, observed: 261.0.
References:
WO2011/128251,2011,A1 Location in patent:Page/Page column 104-105
