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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List N-Acetyl Lorcaserin
1181690-72-1

N-Acetyl Lorcaserin synthesis

1synthesis methods
846589-98-8 Synthesis
Lorcaserin hydrochloride

846589-98-8
0 suppliers
$31.00/1mg

75-36-5 Synthesis
Acetyl chloride

75-36-5
591 suppliers
$17.92/100G

N-Acetyl Lorcaserin

1181690-72-1
14 suppliers
inquiry

-

Yield:-

Reaction Conditions:

with triethylamine in dichloromethane at 20; for 0.5 h;

Steps:

1.29.A

Step A: Preparation of ()-l-(8-Chloro-l-methyl-4,5-dihydro-lH-benzo[d]azepin- 3(2H)-yl)ethanone.To a solution of (i?)-8-chloro-l-methyl-2,3,4,5-tetrahydro-lH-benzo[d]azepine hydrochloride (0.108 g, 0.465 mmol) in DCM (3 mL) was added triethylamine (0.259 mL, 1.861 mmol) and acetyl chloride (0.043 mL, 0.605 mmol). The reaction was stirred for 30 min at room temperature. The mixture was concentrated to give the title compound (304 mg) without further purification. LCMS m/z = 238.1 [M+H]+.

References:

WO2009/105206,2009,A1 Location in patent:Page/Page column 74-75

N-Acetyl Lorcaserin Related Search:

2H-3-Benzazepin-2-one, 8-chloro-1,3,4,5-tetrahydro-1-Methyl- LORAZEPAM RELATED COMPOUND D (25 MG) (6-CHLORO-4-(O-CHLOROPHENYL)-2-QUINAZOLINECAR-BOXYLIC ACID)