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Lorcaserin hydrochloride

Lorcaserin hydrochloride Structure
Lorcaserin hydrochloride structure
CAS No.
846589-98-8
Chemical Name:
Lorcaserin hydrochloride
Synonyms
LORCASERIN HCL;Lorca Hydrochloride;(R)-1H-3-BENZAZEPINE;LORCASERIN HCL/Belviq;Lorcaserin hydrochloride;R Lorcaserin hydrochloride;Lorcaserin Hydrochloride (>Thiosildenafil Solution, 100ppm;Lorcaserin (hydrochloride) (CRM);Lorcaserin Hydrochloride (>50% ee)
CBNumber:
CB82451004
Molecular Formula:
C11H15Cl2N
Molecular Weight:
232.15
MDL Number:
MFCD09833667
MOL File:
846589-98-8.mol
Last updated:2024-03-07 10:32:25
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Lorcaserin hydrochloride Properties

solubility Soluble in DMSO > 10 mM
form Powder
Stability Hygroscopic
FDA UNII 0QJF08GDPE

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P240-P241-P242-P243-P260-P264-P270-P271-P280-P301+P310-P321-P330-P303+P361+P353-P304+P340-P307+P311-P312-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
0 0

Lorcaserin hydrochloride price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15521 Lorcaserin (hydrochloride) ≥98% 846589-98-8 1mg $32 2024-03-01 Buy
Cayman Chemical 15521 Lorcaserin (hydrochloride) ≥98% 846589-98-8 5mg $86 2024-03-01 Buy
Cayman Chemical 19247 Lorcaserin (hydrochloride) (CRM) 846589-98-8 1mg $238 2024-03-01 Buy
American Custom Chemicals Corporation API0024533 LORCASERIN HYDROCHLORIDE 95.00% 846589-98-8 5MG $504.69 2021-12-16 Buy
DC Chemicals DC8644 LorcaserinHydrochloride 99% 846589-98-8 1g $600 2021-12-16 Buy
Product number Packaging Price Buy
15521 1mg $32 Buy
15521 5mg $86 Buy
19247 1mg $238 Buy
API0024533 5MG $504.69 Buy
DC8644 1g $600 Buy

Lorcaserin hydrochloride Chemical Properties,Uses,Production

Description

In June 2012, the US FDA approved lorcaserin for chronic weight management in adult patients who are characterized as overweight or obese and have at least one comorbid, weight-related condition. Lorcaserin (also known as APD356) is the first 5-HT2C agonist approved for chronic weight management since the withdrawal of the 5-HT2C agonist fenfluramine in 1997 due to rare cases of cardiac valvulopathy. The serotonin receptor 5-HT2C is found primarily in the hypothalamus and regulates appetite and feeding behavior. Safety issues with fenfluramine were associated with poor selectivity for 5-HT2C versus 5HT2A and 5HT2B. Ring constraint afforded by the benzazepine in lorcaserin improved selectivity for 5HT2C by over 2 log units.

Description

Lorcaserin (hydrochloride) (CRM) (Item No. 19247) is a certified reference material categorized as an anorectic. It also decreases oxycodone intake and has positive effects on self-administration and relapse vulnerability in the rat. Lorcaserin is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.

Originator

Pharmaceuticals (United States)

Uses

Lorcaserin hydrochloride, a novel antiobesity drug, is a selective serotonin 5-HT2C receptor agonist, approved by FDA in 2012.

Definition

ChEBI: A hydrochloride obtained by reaction of lorcaserin with one equivalent of hydrochloric acid. Used as an anti-obesity drug.

brand name

Belviq

Side effects

Lorcaserin hydrochloride (Belviq) is a serotonin 2C receptor agonist that causes weight loss by causing appetite suppression.It appears to have fewer adverse effects than orlistat,although long-term safety data are limited. The recommended dosage is 10mg twice daily. Lorcaserin should be discontinued if patients do not lose 5% of their body weight in 12 weeks. The efficacy of lorcaserin appears similar to that of orlistat (mean difference in weight loss between active and placebo-treated groups approximately 3-4 kg).Common side effects include nausea, headache,dizziness, nasopharyngitis, and fatigue. Lorcaserin may increasethe risk of symptomatic hypoglycemia in patients with type 2 diabetes on oral agents, necessitating a reduction in the dose of diabetes medications. Lorcaserin should not be used in individuals with creatinine clearance <30 mL/minute. It is contraindicated during pregnancy. In addition, lorcaserin should not be used with other serotonergic drugs (e.g., selective serotonin reuptake inhibitors,selective serotonin-norepinephrine reuptake inhibitors, bupropion[Wellbutrin], tricyclic antidepressants,and monamine oxidase inhibitors)because of the theoretical potential for serotonin syndrome.
https://www.accessdata.fda.gov
https://medlineplus.gov

Drug interactions

Belviq (lorcaserin hydrochloride) may interact with antidepressants, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs), triptans, bupropion, dextromethorphan, or St. John's Wort.

Precautions

The precautions of BELVIQ (lorcaserin hydrochloride) tablets:
Serotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)- like Reactions: The safety of coadministration with other serotonergic or antidopaminergic agents has not been established.
Valvular heart disease: If signs or symptoms develop, consider BELVIQ discontinuation and evaluate the patient for possible valvulopathy.
Cognitive Impairment: This may cause disturbances in attention or memory. Caution with the use of hazardous machinery when starting BELVIQ treatment.
Psychiatric Disorders, including euphoria and dissociation: Do not exceed the recommended dose of 10 mg twice daily.
Monitor for depression or suicidal thoughts. Discontinue if symptoms develop.
Use of Antidiabetic Medications: Weight loss may cause hypoglycemia. Monitor blood glucose. BELVIQ has not been studied in patients taking insulin.
Priapism: Patients should seek emergency treatment if an erection lasts >4 hours. Use BELVIQ with caution in patients predisposed to priapism.

Lorcaserin hydrochloride synthesis

616201-80-0
846589-98-8
Synthesis of Lorcaserin hydrochloride from LorcaserinA

Lorcaserin hydrochloride Preparation Products And Raw materials

Raw materials

LorcaserinA 1H-3-Benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-Methyl-, (1S)-

Preparation Products

Lorcaserin hydrochloride Suppliers

Global( 246)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Hangzhou ICH Biofarm Co., Ltd 		+undefined8613073685410 sales@ichemie.com China 985 58
Wuhan Haorong Biotechnology Co.,ltd 		+8618565342920 sales@chembj.net China 269 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		+86 18953170293 sales@sdzschem.com China 2931 58
Supplier Advantage
Hebei Yanxi Chemical Co., Ltd. 		58
Hangzhou ICH Biofarm Co., Ltd 		58
Wuhan Haorong Biotechnology Co.,ltd 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Nanjing Finetech Chemical Co., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		58

Related articles

View Lastest Price from Lorcaserin hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lorcaserin hydrochloride pictures 2024-04-24 Lorcaserin hydrochloride
846589-98-8
 US $0.00-0.00 / kg 1kg 99% 500 Wuhan Haorong Biotechnology Co.,Ltd
Lorcaserin hydrochloride pictures 2024-01-02 Lorcaserin hydrochloride
846589-98-8
 US $30.00-300.00 / KG 1KG 0.99 20 tons Zibo Hangyu Biotechnology Development Co., Ltd
（R）Lorcaserin hydrochloride pictures 2023-11-01 （R）Lorcaserin hydrochloride
846589-98-8
 US $0.00-0.00 / kg 1kg 99% 10tons Hangzhou ICH Biofarm Co., Ltd

846589-98-8(Lorcaserin hydrochloride)Related Search:

Lorcaserin HCl Hemihydrate impurity Bortezomib IWR-1-endo VE-821 VS-5584
Entinostat AMG-706 (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine hydrochloride hemihydrate Green Cardinal Impurity C Chlorophyll hydrochloride hemihydrate
S type - green card color forest R-green cardin Green card color forest impurity D Green cardinin racemate Green Cardinal Impurity A
LORCASERIN 7-CHLORO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE Lorcaserin hydrochloride

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(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE Lorcaserin hydrochloride (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (1R)-8-chloro-1-Methyl-2,3,4,5-tetrahydro-1H-3-benzazepine lorcaserin hydrochloride (APD-356) R Lorcaserin hydrochloride Green Card mianserin hydrochloride (R)-1H-3-BENZAZEPINE (R)-8-Chloro-1-Methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride Lorcaserin Hydrochloride (>50% ee) 1H-3-Benzazepine,8-chloro-2,3,4,5-tetrahydro-1-Methyl-, hydrochloride (1:1), (1R)- Thiosildenafil Solution, 100ppm Lorcaserin hydrochloride, 98%, a selective full agonist of human 5-HT2C receptor Lorcaserin (hydrochloride) (CRM) LORCASERIN HCL;APD-356;APD356;APD 356 Lorcaserin Hydrochloride (> Lorcaserin Hydrochloride Solution in Methanol, 1000 ug/ml R-Lorcaserin hydrochloride USP/EP/BP (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE USP/EP/BP Lorcaserin HCl , Lorcaserin Hydrochloride C11H15Cl2N (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE 846589-98-8 LORCASERIN HCL Lorca Hydrochloride Lorcaserin hydrochloride GMP Standard Raw Powder (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE LORCASERINE （Int.） LORCASERIN HCL/Belviq 846589-98-8 646202-80-0 616202-80-0 APIs 5-HT 2c receptor agonist Inhibitors 1