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(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE
(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE structure
CAS No.
846589-98-8
Chemical Name:
(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE
Synonyms
LORCASERIN HCL;(R)-1H-3-BENZAZEPINE;Lorcaserin hydrochloride;R Lorcaserin hydrochloride;Thiosildenafil Solution, 100ppm;Lorcaserin (hydrochloride) (CRM);lorcaserin hydrochloride (APD-356);Lorcaserin Hydrochloride (>50% ee);Green Card mianserin hydrochloride;(1R)-8-chloro-1-Methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CBNumber:
CB82451004
Molecular Formula:
C11H15Cl2N
Formula Weight:
0
MOL File:
846589-98-8.mol

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15521 Lorcaserin (hydrochloride) ≥98% 846589-98-8 1mg $59 2018-11-13 Buy
Cayman Chemical 15521 Lorcaserin (hydrochloride) ≥98% 846589-98-8 5mg $148 2018-11-13 Buy
Cayman Chemical 19247 Lorcaserin (hydrochloride) (CRM) 846589-98-8 1mg $195 2018-11-19 Buy

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE Chemical Properties,Uses,Production

Description

In June 2012, the US FDA approved lorcaserin for chronic weight management in adult patients who are characterized as overweight or obese and have at least one comorbid, weight-related condition. Lorcaserin (also known as APD356) is the first 5-HT2C agonist approved for chronic weight management since the withdrawal of the 5-HT2C agonist fenfluramine in 1997 due to rare cases of cardiac valvulopathy. The serotonin receptor 5-HT2C is found primarily in the hypothalamus and regulates appetite and feeding behavior. Safety issues with fenfluramine were associated with poor selectivity for 5-HT2C versus 5HT2A and 5HT2B. Ring constraint afforded by the benzazepine in lorcaserin improved selectivity for 5HT2C by over 2 log units.

Originator

Pharmaceuticals (United States)

Uses

Anti-obesity (activate 5-HT2creceptor).

Definition

ChEBI: A hydrochloride obtained by reaction of lorcaserin with one equivalent of hydrochloric acid. Used as an anti-obesity drug.

brand name

Belviq

(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products


(R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE Suppliers

Global( 147)Suppliers
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Shenzhen Sendi Biotechnology Co.Ltd.
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View Lastest Price from (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-16 (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE
846589-98-8
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2018-12-15 (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE
846589-98-8
US $8.00 / kg 1kg 98% 100KG career henan chemical co

846589-98-8((R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE)Related Search:


  • R Lorcaserin hydrochloride
  • lorcaserin hydrochloride (APD-356)
  • (R)-8-Chloro-1-Methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride
  • Lorcaserin Hydrochloride (>50% ee)
  • 1H-3-Benzazepine,8-chloro-2,3,4,5-tetrahydro-1-Methyl-, hydrochloride (1:1), (1R)-
  • Green Card mianserin hydrochloride
  • (R)-1H-3-BENZAZEPINE
  • Thiosildenafil Solution, 100ppm
  • Lorcaserin hydrochloride, 98%, a selective full agonist of human 5-HT2C receptor
  • Lorcaserin (hydrochloride) (CRM)
  • (R)-1H-3-BENZAZEPINE,8-CHLORO-2,3,4,5-TETRAHYDRO-1-METHYL-,HYDROCHLORIDE
  • LORCASERIN HCL
  • Lorcaserin hydrochloride
  • (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
  • (1R)-8-chloro-1-Methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
  • 846589-98-8
  • 646202-80-0
  • 616202-80-0
  • -
  • 5-HT 2c receptor agonist
  • Inhibitors
  • APIs
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