
N-Boc-Trans-4-Hydroxy-D-proline methyl ester synthesis
- Product Name:N-Boc-Trans-4-Hydroxy-D-proline methyl ester
- CAS Number:135042-17-0
- Molecular formula:C11H19NO5
- Molecular Weight:245.27

481704-21-6
121 suppliers
$11.00/250mg

24424-99-5
863 suppliers
$13.50/25G

135042-17-0
174 suppliers
$8.00/250mg
Yield:135042-17-0 100%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in 1,4-dioxane at 0 - 20; for 1 h;
Steps:
7
Add di-tert-butyl dicarbonate (11.2 g, 51.35 mmol) to a solution of 4-(S)- hydroxypyrrolidine-2- (R)-carboxylic acid methyl ester hydrochloride (7.17 g, 39.5 mmol) in 1,4-dioxane (80 mL). Cool in an ice bath and add N,N-diisopropylethylamine (11.7 mL, 67.2 mmol). Remove ice bath and stir 1 h at room temperature. Concentrate and dissolve in ethyl acetate, wash with 5% aqueous citric acid solution (2 x100 mL), water, saturated aqueous sodium bicarbonate, saturated aqueous sodium chloride, dry (magnesium sulfate), concentrate and purify (silica gel chromatography, eluting with hexanes and ethyl acetate) to give the title compound as a white solid (9.83 g, 100%). MS (ES): m/z = 246.1 [M+H].
References:
WO2005/108358,2005,A2 Location in patent:Page/Page column 38-39
![1,2-Pyrrolidinedicarboxylic acid, 4-[(4-nitrobenzoyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4S)-](/CAS/20210305/GIF/361367-93-3.gif)
361367-93-3
0 suppliers
inquiry

135042-17-0
174 suppliers
$8.00/250mg

147266-92-0
178 suppliers
$60.00/100mg

74-88-4
351 suppliers
$15.00/10g

135042-17-0
174 suppliers
$8.00/250mg

24424-99-5
863 suppliers
$13.50/25G

178962-09-9
33 suppliers
inquiry

135042-17-0
174 suppliers
$8.00/250mg

147266-92-0
178 suppliers
$60.00/100mg

18107-18-1
214 suppliers
$33.00/5g

135042-17-0
174 suppliers
$8.00/250mg