N-Butyl-2-chloronicotinamide synthesis
- Product Name:N-Butyl-2-chloronicotinamide
- CAS Number:56149-32-7
- Molecular formula:C10H13ClN2O
- Molecular Weight:212.68
Yield:56149-32-7 70%
Reaction Conditions:
in dichloromethane at 0 - 20; for 4 h;
Steps:
5.1.11 General procedure for the preparation of 9a-d
General procedure: The mixture of 2-chloronicotinoylchloride (8) in last step was dissolved in anhydrous CH2Cl2 (10 mL) and then added dropwise to a CH2Cl2 (10 mL) solution of the corresponding amine (15 mmol) cooled at 0 °C under stirring. The mixture was allowed to warm to room temperature and stirring was continued for additional 4 h. After treatment of the reaction mixture with a 5% solution of sodium hydroxide (15 mL) and separation of the organic layer, the aqueous phase was extracted with ethyl acetate (3 × 15 mL) to recover further product. The combined organic extracts were dried (Na2SO4) and evaporated under reduced pressure. The residue was purified by flash chromatography on silica gel using dichloromethane/acetone (30:1).
References:
Zhang, Zhichao;Liu, Chengwu;Li, Xiangqian;Song, Ting;Wu, Zhiyong;Liang, Xiaomeng;Zhao, Yan;Shen, Xiaoyun;Chen, Hongbo [European Journal of Medicinal Chemistry,2013,vol. 60,p. 410 - 420]
2942-59-8
828 suppliers
$5.00/25g
56149-32-7
8 suppliers
inquiry
6602-54-6
509 suppliers
$6.00/10g
56149-32-7
8 suppliers
inquiry