N-(carbamothioylamino)-2-phenylacetamide synthesis
- Product Name:N-(carbamothioylamino)-2-phenylacetamide
- CAS Number:29313-28-8
- Molecular formula:C9H11N3OS
- Molecular Weight:209.27
Yield:29313-28-8 22%
Reaction Conditions:
with pyridine in N,N-dimethyl-formamide at 20; for 8 h;
Steps:
A solution of phenylacetyl chloride (5.27ml_, 0.04 mol.) in DMF (100 ml.) was added at room temperature to a solution of thiosemicarbazide (3.64g, 0.04 mol.) and pyridine (3.23 ml_, 0.04 mol.) in DMF. After stirring for 8 hours, the mixture was poured into iced water and the pH was adjusted to 9 with ammonia. After extraction of the aqueous layer with ethyl acetate, the organic layer was washed with water, dried on Na2SO4 and after filtration was evaporated to dryness. Then the residue was recrystallized in ethyl acetate to give the title compound as a solid (1.878g, 22%). LC/MS: m/z 210 (IvRH)+, Rt: 1.75 min.
References:
WO2008/104524,2008,A1 Location in patent:Page/Page column 52
103-82-2
0 suppliers
$27.60/100g
29313-28-8
7 suppliers
inquiry
101-41-7
522 suppliers
$16.80/100ML
29313-28-8
7 suppliers
inquiry
937-39-3
129 suppliers
$10.00/1g
29313-28-8
7 suppliers
inquiry