N-Ethynyl-N,4-dimethylbenzenesulfonamide synthesis
- Product Name:N-Ethynyl-N,4-dimethylbenzenesulfonamide
- CAS Number:1005500-75-3
- Molecular formula:C10H11NO2S
- Molecular Weight:209.26
79-00-5
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Yield:1005500-75-3 90%
Reaction Conditions:
with sodium hydride in N,N-dimethyl-formamide at 80; for 1 h;Schlenk technique;
Steps:
1 Example 1
0.2 mmol of N-methyl-p-toluenesulfonamide and a stir bar were added to a clean Schlenk reaction tube, and then 1.0 mL of DMF solvent was added by a syringe.Add 1.4 mmol of NaH to the reaction tube.Finally, 1.0 mmol of 1,1,2-trichloroethane was added using a micro syringe.Then, the bottle mouth was stoppered with a soft rubber stopper, and reacted at 80 ° C for 1 hour, and the TLC dot plate was tested;After the reaction was completed, the reaction solution was added with ice water and extracted with ethyl acetate three times.The organic layer was concentrated and then purified by column chromatography to yield90% purified N-methyl-N-ethynyl p-toluenesulfonamide as a white solid.The structural formula of the product and its characterization data are as follows:
References:
Jiangxi Normal University;Xu Silin;Zeng Xianzhu;Wang Hui;Zhao Junfeng CN108689858, 2018, A Location in patent:Paragraph 0025
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