ChemicalBook CAS DataBase List N,N-DIMETHYLNONYLAMINE

N,N-DIMETHYLNONYLAMINE synthesis

12synthesis methods

Product Name:N,N-DIMETHYLNONYLAMINE
CAS Number:17373-27-2
Molecular formula:C11H25N
Molecular Weight:171.32

693-58-3 Synthesis

693-58-3
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17373-27-2
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Yield: 95%

Reaction Conditions:

in ethanol;water for 5 h;Reflux;

Steps:

2.2.3 The preparation of compound 2d (N,N-dimethylnonan-1-amine)
4mL aqueous dimethylamine (33%, m/m, excessive) reacted with 5mmol 1-bromononane in 30mL ethanol under stirring and reflux for 5h, then the mixture was washed by distilled water (3×30mL) to get rid of unreacted dimethylamine. The water phase was extracted by CHCl₃ (3×30mL). The organic phases were combined and dried by Na₂SO₄. After the solvent had been removed under reduced pressure, the crude product (light yellow sticky liquid) was chromatographed on a silica gel column by using dichloromethane as eluents to give product 2d. Yield: 95.0%; Colorless liquid; ¹H NMR (400MHz, CDCl₃) δ: 3.61 (t, J=8.8Hz, 4H,-CH₂NCH₂-), 3.51 (s, 6H,-N(CH₃)₂), 1.73 (m, 2H,-NCH₂CH₂-), 1.23 (m, 12H, 6×-CH₂-), 0.84 (t, J=7.2Hz, 3H,-CH₃); ESI-MS, m/z: 172.24[M+H]⁺.

References:

Zheng, Yanyan;Zhu, Li;Fan, Lulu;Zhao, Wenna;Wang, Jianlong;Hao, Xianxiao;Zhu, Yunhui;Hu, Xiufang;Yuan, Yaofeng;Shao, Jingwei;Wang, Wenfeng [European Journal of Medicinal Chemistry,2017,vol. 125,p. 902 - 913]

124-40-3
534 suppliers
$18.00/100ml