ChemicalBook CAS DataBase List N-PHTHALOYL-DL-GLUTAMIC ANHYDRIDE

N-PHTHALOYL-DL-GLUTAMIC ANHYDRIDE synthesis

6synthesis methods

Product Name:N-PHTHALOYL-DL-GLUTAMIC ANHYDRIDE
CAS Number:3343-28-0
Molecular formula:C13H9NO5
Molecular Weight:259.21

6349-98-0 Synthesis

6349-98-0
42 suppliers
$31.10/5G

3343-28-0
41 suppliers
$45.00/50mg

Yield:3343-28-0 95%

Reaction Conditions:

with acetic anhydride for 0.25 h;Reflux;

Steps:

2.2.2. Synthesis of N-Pht-DL-glutamic anhydride

N-Pht-DL-glutamate (41.6 g) was refluxed in 45 mL acetic anhydride for 15 min, cooled naturally, crystallized, filtered and washed with ethyl acetate for crystallization. Yield: 95%, 36.9 g colorless acicular crystal. 1H NMR (600 MHz, DMSO-d6) δ: 8.00-7.89 (m, 4H), 5.48 (dd, J = 13.0, 5.8 Hz, 1H), 3.17-3.07 (m, 1H),3.03-2.92 (m, 1H), 2.68-2.55 (m, 1H), 2.19-2.07 (m, 1H). 13C NMR(151 MHz, DMSO-d6) δ: 167.18, 166.77, 166.11, 135.52, 131.58, 124.09,48.15, 29.92, 20.87.

References:

Du, Qinglin;Zhang, Xiangyang;Pan, Xinru;Zhang, Hongjuan;Yang, Yu-Shun;Liu, Junzhong;Jiao, Qingcai [Journal of Molecular Structure,2020,vol. 1219,art. no. 128600]

85-44-9 Synthesis