N-(thiophen-2-ylmethyl)cyclohexanamine synthesis
- Product Name:N-(thiophen-2-ylmethyl)cyclohexanamine
- CAS Number:51305-86-3
- Molecular formula:C11H17NS
- Molecular Weight:195.32
10354-42-4
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51305-86-3
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$117.00/1g
Yield:51305-86-3 86%
Reaction Conditions:
Stage #1: N-cyclohexylthiophene-2-carboxamidewith 2-fluoropyridine;trifluoromethylsulfonic anhydride in dichloromethane at -78 - 0;Inert atmosphere;
Stage #2: with triethylsilane in dichloromethane at 0 - 25;Inert atmosphere;
Stage #3: with diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate in dichloromethane at 25; for 12 h;Inert atmosphere;chemoselective reaction;
References:
Pelletier, Guillaume;Bechara, William S.;Charette, Andre B. [Journal of the American Chemical Society,2010,vol. 132,# 37,p. 12817 - 12819] Location in patent:supporting information; experimental part
98-03-3
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51305-86-3
21 suppliers
$117.00/1g