N-TRIFLUOROACETYLGLYCINE, N-SUCCINIMIDYL ESTER synthesis
- Product Name:N-TRIFLUOROACETYLGLYCINE, N-SUCCINIMIDYL ESTER
- CAS Number:3397-30-6
- Molecular formula:C8H7F3N2O5
- Molecular Weight:268.15
6066-82-6
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$5.00/10g
383-70-0
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$20.00/1G
3397-30-6
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$85.00/10mg
Yield:3397-30-6 100%
Reaction Conditions:
with 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane at 0;Solvent;
Steps:
3.3. General Procedure for the Preparation of TFA-a-Amino Acid N-Hydroxysuccinimide Ester
General procedure: NHS (N-hydroxysuccinimide, 1.1 equiv.) was added to a solution of TFA--amino acid(L-/D-1a-L-/D-2a, 3a, L-/D-4a-L-/D-8a, 1.0 mmol) in pre-cooled CH2Cl2 (10 mL). The suspensionof WSCD-HCl (water soluble carbodiimide hydrochloride, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride, 1.0 equiv.) in CH2Cl2 (10 mL) was added drop-wise at 0 Cand the reaction was stirred for 2-4 h. The solvent was removed by rotary evaporation. The residuethat remained was dissolved in ethyl acetate; washed with water, sat. NaHCO3, sat. NaCl, dried overMgSO4, and then evaporated. The product was solidified by washing with hexane to be used for further reaction.
References:
Tachrim, Zetryana Puteri;Oida, Kazuhiro;Ikemoto, Haruka;Ohashi, Fumina;Kurokawa, Natsumi;Hayashi, Kento;Shikanai, Mami;Sakihama, Yasuko;Hashidoko, Yasuyuki;Hashimoto, Makoto [Molecules,2017,vol. 22,# 10,art. no. 1748] Location in patent:supporting information
74124-79-1
476 suppliers
$5.00/5g
383-70-0
120 suppliers
$20.00/1G
3397-30-6
19 suppliers
$85.00/10mg