ChemicalBook CAS DataBase List NIPECOTAMIDE

NIPECOTAMIDE synthesis

4synthesis methods

Product Name:NIPECOTAMIDE
CAS Number:4138-26-5
Molecular formula:C6H12N2O
Molecular Weight:128.17

98-92-0 Synthesis

98-92-0
1166 suppliers
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4138-26-5
196 suppliers
$11.00/5g

Yield:4138-26-5 98.4%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in isopropyl alcohol at 75; under 3750.38 Torr; for 4 h;

Steps:

122.12 g (1.00 mol) of nicotinamide was dissolved in 500 mL of 2-propanol. To the resulting solution was charged 14.4 g of palladium-carbon (10%), and the solution was stirred for 4 hours at 75° C. under hydrogen pressure of 0.5 MPa. After the reaction was completed, the palladium-carbon was filtered and separated. The filtered palladium-carbon was washed with 100 mL of 2-propanol. The filtrate and the washing liquid were combined and condensed, and 126.08 g of white crystals of nipecotamide in a racemic form was obtained. The yield was 98.4%. The resultant was confirmed to be the target object by NMR.

References:

SUMITOMO CHEMICAL COMPANY, LIMITED US2012/123128, 2012, A1 Location in patent:Page/Page column 3

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98-92-0 Synthesis

98-92-0
1166 suppliers
$5.00/5g

4138-26-5
196 suppliers
$11.00/5g

7032-11-3 Synthesis