NIPECOTAMIDE
- CAS No.
- 4138-26-5
- Chemical Name:
- NIPECOTAMIDE
- Synonyms
- NIPECOTAMIDE;Nipecotamide>Nipecotamide,95%;Nipecotamide,97%;TIMTEC-BB SBB004239;nipecotic acid amide;NipecotaMide, 95% 5GR;HEXAHYDRONICOTINAMIDE;3-Carbamoylpiperidine;Butafenacil Impurity 5
- CBNumber:
- CB9345421
- Molecular Formula:
- C6H12N2O
- Molecular Weight:
- 128.17
- MDL Number:
- MFCD00005993
- MOL File:
- 4138-26-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Nipecotamide 95% | N8105 | 10g | $94.6 |
| Nipecotamide >98.0%(T) | N0097 | 5g | $51 |
| Nipecotamide >98.0%(T) | N0097 | 25g | $133 |
| Nipecotamide | 460778 | 1g | $305 |
| Nipecotamide | 284950 | 10g | $382 |
| More product size | |||
| Melting point | 103-106 °C(lit.) |
|---|---|
| Boiling point | 237.61°C (rough estimate) |
| Density | 1.0754 (rough estimate) |
| refractive index | 1.4880 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | Crystalline Powder |
| pka | 16.50±0.20(Predicted) |
| color | Yellow |
| InChI | InChI=1S/C6H12N2O/c7-6(9)5-2-1-3-8-4-5/h5,8H,1-4H2,(H2,7,9) |
| InChIKey | BVOCPVIXARZNQN-UHFFFAOYSA-N |
| SMILES | N1CCCC(C(N)=O)C1 |
| CAS DataBase Reference | 4138-26-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39 |
| WGK Germany | 3 |
| HS Code | 29339900 |
NIPECOTAMIDE price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N8105 | Nipecotamide 95% | 4138-26-5 | 10g | $94.6 | 2022-05-15 | Buy |
| TCI Chemical | N0097 | Nipecotamide >98.0%(T) | 4138-26-5 | 5g | $51 | 2025-07-31 | Buy |
| TCI Chemical | N0097 | Nipecotamide >98.0%(T) | 4138-26-5 | 25g | $133 | 2025-07-31 | Buy |
| Usbiological | 460778 | Nipecotamide | 4138-26-5 | 1g | $305 | 2021-12-16 | Buy |
| Usbiological | 284950 | Nipecotamide | 4138-26-5 | 10g | $382 | 2021-12-16 | Buy |
NIPECOTAMIDE Chemical Properties,Uses,Production
Chemical Properties
YELLOW CRYSTALLINE POWDER
Uses
Reactant for synthesis of:• ;DPP-4 inhibitors1• ;IKKβ inhibitors2• ;Spiroimidazolidinone NPC1L1 inhibitors3• ;Sulfamides4• ;Phosphodiesterase 5 inhibtors5• ;Anti-HIV agents6
Uses
Nipecotamide, is a budiling blcok used in the sythnesis of various compounds, such as DPP-4 inhibitors, IKKβ inhibitors, piroimidazolidinone NPC1L1 inhibitors, and Anti-HIV agents.
Definition
ChEBI: The amide resulting from the formal condensation of nipecotic acid with ammonia.
Synthesis
98-92-0
4138-26-5
122.12 g (1.00 mol) of nicotinamide was dissolved in 500 mL of 2-propanol. To this solution was added 14.4 g of 10% palladium-carbon catalyst, followed by stirring the reaction for 4 hours at 75 °C under 0.5 MPa hydrogen pressure. Upon completion of the reaction, the palladium-carbon catalyst was removed by filtration and the filter cake was washed with 100 mL of 2-propanol. The filtrate and washings were combined and concentrated to give 126.08 g of racemic 3-piperidinecarboxamide white crystals in 98.4% yield. The structure of the product was confirmed by NMR characterization.
References
[1] Patent: US2012/123128, 2012, A1. Location in patent: Page/Page column 3
[2] Synlett, 2006, # 9, p. 1440 - 1442
[3] Chemistry - A European Journal, 2009, vol. 15, # 28, p. 6953 - 6963
[4] Synlett, 2008, # 8, p. 1125 - 1128
[5] Journal of the American Chemical Society, 1949, vol. 71, p. 1680
NIPECOTAMIDE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3587 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21616 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Zjartschem | +86-571 87238903 | jocelynpan@zjarts.com | CHINA | 988 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
View Lastest Price from NIPECOTAMIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-25 | NIPECOTAMIDE
4138-26-5
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2024-05-18 | NIPECOTAMIDE
4138-26-5
|
US $1.00-25.00 / KG | 1KG | 99%+ | 1076KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-09-02 | NIPECOTAMIDE
4138-26-5
|
US $7.00 / KG | 1KG | 99% | JD 533 | Career Henan Chemical Co |
-
- NIPECOTAMIDE
4138-26-5
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- NIPECOTAMIDE
4138-26-5
- US $1.00-25.00 / KG
- 99%+
- Shaanxi Dideu Medichem Co. Ltd
-
- NIPECOTAMIDE
4138-26-5
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
