NORCAMPHORICACID synthesis
- Product Name:NORCAMPHORICACID
- CAS Number:4056-78-4
- Molecular formula:C7H10O4
- Molecular Weight:158.15
498-66-8
4056-78-4
A mechanical stirrer, J-KEM temperature controller and nitrogen inlet were assembled in a 22 L three-necked round bottom flask. Norbornene (200 g, 2.123 mol), ethyl acetate (1.95 L) and acetonitrile (1.95 L) were added sequentially. The reaction mixture was cooled to 5 °C using an acetone/dry ice bath. Ruthenium trichloride (9.69 g, 46.72 mmol) was added in batches, followed by a slow dropwise addition of an aqueous (2.925 L) suspension of sodium periodate (1.816 kg, 8.707 mol) over 30 min. The reaction became exothermic and was controlled between 10 °C and 15 °C. After 90 min, the reaction mixture thickened significantly, stirring was difficult, and the temperature rose rapidly to 39 °C (exotherm was controlled by replenishing the cooling bath with large amounts of dry ice). The reaction mixture was cooled to 20 °C, the cooling bath was withdrawn and stirring was continued overnight at room temperature. The reaction mixture was filtered through a diatomaceous earth pad to remove solids and the filtrate was concentrated until solids precipitated. The solid was ground with hexane (2 L), filtered and washed with hexane (2 x 500 mL) to give 195 g of cyclopentane-1,3-dicarboxylic acid (58% yield). The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 12.07 (s, 2H), 2.66-2.73 (m, 2H), 2.06-2.12 (m, 1H), 1.85-1.89 (m, 1H), 1.72-1.85 (m, 4H).
497-38-1
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4056-78-4
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Yield:-
Steps:
Multi-step reaction with 3 steps
1: liq. NH3
2: P2O5 / benzene / Heating
3: KMnO4, aq. KOH
References:
Kagawa,M. [Chemical and pharmaceutical bulletin,1961,vol. 9,p. 391 - 403]
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101 suppliers
$27.00/250mg