
P-fluorophenyltriMethoxysilane synthesis
1synthesis methods
- Product Name:P-fluorophenyltriMethoxysilane
- CAS Number:53883-61-7
- Molecular formula:C9H13FO3Si
- Molecular Weight:216.2816
Yield: 64%
Reaction Conditions:
Stage #1:1-Bromo-4-fluorobenzene with hydrogenchloride;iodine;magnesium in methanol;diethyl etherReflux;
Stage #2:tetramethylorthosilicate in methanol;diethyl ether at -5 - 23;
References:
Visco, Michael D.;Wieting, Joshua M.;Mattson, Anita E. [Organic Letters,2016,vol. 18,# 12,p. 2883 - 2885] Location in patent:supporting information