Panobinostat lactate synthesis
- Product Name:Panobinostat lactate
- CAS Number:960055-56-5
- Molecular formula:C3H6O3*C21H23N3O2
- Molecular Weight:0
849585-22-4
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960055-56-5
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Yield:960055-56-5 86.2%
Reaction Conditions:
in water;acetone at 0 - 20;Product distribution / selectivity;Cooling with ice;
Steps:
19
3.67 g (10 mmol) of the free base form HA (N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide) and 75 mL of acetone were charged in a 250 mL 3-neck flask equipped with a magnetic stirrer and an addition funnel. To the stirred suspension were added dropwise 10 mL of 1 M lactic acid in water (10 mmol) dissolved in 20 mL acetone, affording a clear solution. Stirring continued at ambient and a white solid precipitated out after approximately 1 hour. The mixture was cooled in an ice bath and stirred for an additional hour. The white solid was recovered by filtration and washed once with cold acetone (15 mL). It was subsequently dried under vacuum to yield 3.94 g of the DL-lactate monohydrate salt of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide (86.2%).
References:
US2009/192210,2009,A1 Location in patent:Page/Page column 14
![N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide DL-lactate monohydrate](/CAS/20210111/GIF/960055-68-9.gif)
960055-68-9
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2731-06-8
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100-63-0
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960055-56-5
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5891-21-4
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