ChemicalBook CAS DataBase List Penicillin G potassium salt

Penicillin G potassium salt synthesis

3synthesis methods

Product Name:Penicillin G potassium salt
CAS Number:113-98-4
Molecular formula:C16H17KN2O4S
Molecular Weight:372.48

Penicillin G potassium salt is a highly effective and low toxicity antibiotic, which is obtained by salt formation of Chlorpheniramine maleate and maleic acid.

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113-98-4
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$7.00/250mg

Yield:113-98-4 94.5%

Reaction Conditions:

with potassium carbonate in acetic acid butyl ester;water;butan-1-ol at 45 - 48;Product distribution / selectivity;

Steps:

2

A series of experiments was carried out in which to 1000 ml of an activated- carbon-treated extract containing approximately 100,000 Oxford Units Penicillin G per ml in n-butylacetate, a 50% (w/w) solution of K₂CO₃ in water was added such that the mixture contained approximately 1.0 mole-equivalent of potassium with regard to penicillin G. The resulting mixture was heated under vacuum using a rotary film evaporator (bath 45-48⁹C) whereby a certain quantity of the mixture was evaporated - see Table 1 for the amount for each experiment. Subsequently, methanol was added to the residue and the mixture was agitated during 1 h at 25^. The suspension was filtered and the wet cake was washed with 70 ml n-butylacetate after which the wet cake was dried.Table 1 : cr stallization of Pen G K in n-but lacetate + addition of methanol to the residue The volume evaporated is the total volume evaporated and the value in brackets represents the volume of the water layer in the distillate. The column with the water content represents the water content of the residue after evaporation. All experiments yielded white Pen G K crystals in high yield (as defined hereinbefore) with regard to the penicillin content in the carbon treated extract (=100%) and only limited penicillin losses to the mother liquor. The crystals from experiment 1 contained 99.3% Pen G K (i.e. good quality).

References:

WO2007/63107,2007,A1 Location in patent:Page/Page column 7-8

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, 2-propenyl ester (9CI)

80127-23-7
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58105-49-0
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113-98-4
441 suppliers
$7.00/250mg

References

80127-23-7
0 suppliers
inquiry

113-98-4
441 suppliers
$7.00/250mg

References

Penicillin G potassium salt Related Search:

Potassium Acetate Heptane Potassium iodide Sodium 1-heptanesulfonate Potassium bromate D-Penicillamine Potassium